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A laboratory trial was conducted to investigate the efficacy and secondary toxicity of chlorophaoinone oats as a prairie dog toxicant. Bait containing 0.0025% chlorophacinone killed 29 of 31 prairie dogs when offered in 25 gram amounts daily for 6 days. Five of 6 domestic ferrets died of anticoagulant poisoning when fed H of these toxicant-kil led prairie dogs over 8 days. Chlorophacinone may not be an acceptable prairie dog toxicant due to this potential secondary hazard.