USDA Agricultural Research Service --Lincoln, Nebraska

 

Date of this Version

2013

Document Type

Article

Citation

Published in Journal of Virology (April 2013) 87:8, p. 4756-4761. DOI: 10.1128 /JVI.02792-12

Abstract

Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.

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