Comparison of immune and adverse effects induced by AdjuVac and Freund's complete adjuvant in New Zealand white rabbits (Oryctolagus cuniculus)

Authors

Jenny G. Powers, National Wildlife Research Center, Animal and Plant Health Inspection Service, United States Department of Agriculture
Paul B. Nash, National Wildlife Research Center, Animal and Plant Health Inspection Service, United States Department of Agriculture
Jack C. Rhyan, National Wildlife Research Center, Animal and Plant Health Inspection Service, United States Department of Agriculture
Christi A. Yoder, National Wildlife Research Center, Animal and Plant Health Inspection Service, United States Department of Agriculture
Lowell A. Miller, National Wildlife Research Center, Animal and Plant Health Inspection Service, United States Department of AgricultureFollow

Date of this Version

October 2007

Comments

Published in LAB ANIMAL Volume 36, No. 9, 1 OCTOBER 2007.

Abstract

Though Freund's complete adjuvant effectively increases immune response to vaccines in various species, its potentially severe inflammatory effects have led many animal researchers to seek alternative immunological adjuvants. In a study of New Zealand white rabbits, the authors compared the immune and adverse effects of Freund's complete adjuvant with the effects of two formulations of AdjuVac, an immunological adjuvant previously developed by their group. ALL three adjuvants improved humoral immune response but also caused inflammation. Inflammatory reactions caused by AdjuVac, however, tended to be Less severe than those caused by Freund's complete adjuvant.