This study was designed to investigate the effect of Librarians initiated HIV/AIDS preventions intervention efforts in selected rural communities in Oyo State, Nigeria. One hundred and ninety two respondents composed of male and female family heads, wives and unmarried adults were randomly chosen for the study. Data were procured through administration of pre-tested and validated interview schedule. About 72% of the respondents gained knowledge of HIV/AIDS through UNDP campaigns, among other sources. Knowledge of contracting HIV/AIDS (unprotected sexual intercourse, blood transfusion, etc), and prevention of the pandemic (use of condom, non-sharing of sharp objects, etc) were also learnt mainly through UNDP activities. Perceptive adverse effects of the pandemic on the society included death, psychological depression and loss of manpower. Other adverse effects were low household income, household food insecurity, diversion of most family labor and funds to healthcare, and inability to eat well. Age ( _2 = 87.106, p=0.00), Primary occupation ( _2 = 12.148, p= .012) and marital status (_2 =47.515, p=0.04) were significantly related to knowledge of prevention of HIV/ AIDS. It is recommended that massive investment in public education and establishment of rural community information resource centres should be intensified through NGOs, librarians and governmental bodies to reduce and eventually eliminate the pandemic.