A Novel Biochamberfor modeling of atherosclerotic arteries: In-vitro Capabilities and Applications

Iman Salafian, University of Nebraska–Lincoln
Angelos Karagiannis, University of Nebraska Medical Center
Benjamin S. Terry, University of Nebraska–Lincoln
Yiannis S. Chatzizisis, University of Nebraska Medical Center

Document Type Article

Copyright © 2017 Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis

Abstract

Atherosclerosis is a chronic disease that involves the lipid accumulation and inflammation of the arterial wall [1,2]. Despite great efforts,its pathophysiology has not been fully elucidated. Existent drugs can reduce its progression but there are no available drugs to prevent its complications [3,4]. Atherosclerosis remains the leading global cause of death[5].

The purpose of this work is to design and build a customized biochamber which can be used for the following studies:

•Study the pathophysiology of atherosclerosis in vitro & ex vivo

•Investigate the mechanisms of atherosclerotic plaque disruption

•Examine the direct effect of different anti-atherosclerotic drugs on lesions

•Use as a stenting simulation device for both research and educational purposes