Mechanical & Materials Engineering, Department of

 

Date of this Version

4-2017

Citation

University of Nebraska-Lincoln Spring 2017 Research Fair, Graduate Student Poster Session, April 5, 2017.

Comments

Copyright © 2017 Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis

Abstract

Atherosclerosis is a chronic disease that involves the lipid accumulation and inflammation of the arterial wall [1,2]. Despite great efforts,its pathophysiology has not been fully elucidated. Existent drugs can reduce its progression but there are no available drugs to prevent its complications [3,4]. Atherosclerosis remains the leading global cause of death[5].

The purpose of this work is to design and build a customized biochamber which can be used for the following studies:

•Study the pathophysiology of atherosclerosis in vitro & ex vivo

•Investigate the mechanisms of atherosclerotic plaque disruption

•Examine the direct effect of different anti-atherosclerotic drugs on lesions

•Use as a stenting simulation device for both research and educational purposes