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Risk-assessment calculations are presented for the preliminary proposed solar minimum and solar maximum orbits for Space Station Freedom (SSF). Integral linear energy transfer (LET) fluence spectra are calculated for the trapped-proton and galactic cosmic ray (GCR) environments. Organ-dose calculations are discussed using the Computerized Anatomical Man model. The cellular track model of Katz is applied to calculate cell survival, transformation, and mutation rates for various aluminum shields. Comparisons between relative biological effectiveness (RBE) and quality factors (QF) for SSF orbits are made, and fluence-dependent effects are discussed.