Radiosensitivity Parameters for Neoplastic Transformations in C3H10T1/2 Cells

Authors

M. P. R. Waligorski, Institute of Nuclear Physics, Krakow, Poland
G. L. Sinclair, University of Nebraska-Lincoln
Robert Katz, University of Nebraska-LincolnFollow

Date of this Version

April 1987

Comments

Published in Radiation Research 111 (1987), pp. 424–437. Copyright © 1987 Academic Press, Inc./Elsevier. Used by permission.

Abstract

We have evaluated radiosensitivity parameters for cellular transformation from published experimental data on neoplastic transformations induced in C3H10T1/2 cells by BEVALAC ions. The measured RBE values are well reproduced by a track theory calculation using sets of m-target parameters with either m = 2 or m = 3, suggesting a quadratic or cubic extrapolation to low doses of γ rays. Using track theory one is thus able to predict transformation frequencies in those cells after an arbitrary radiation field, under known or assumed conditions of exposure, in a manner shown earlier for cellular survival. Extension of these calculations to interpret cancer incidence in vivo is also discussed.