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A large shift of the onset of flux-flow resistivity and the irreversibility line Hirr (T) to higher temperatures is observed in Tl2Ba2Ca2Cu3O10 films containing linear defects created by Ag+21 ion irradiation. The Hirr(T), which has a characteristic ssL shape in highly anisotropic Tl and Bi based cuprates, becomes more like that of YBa2Cu3O7 in the presence of these defects. The Jc at 77 K also shows a large increase as a result of flux localization at the defects. The transport data indicate that in the H-T plane above Hirr (T) of the unirradiated material, an ensemble of unoccupied defects is required for effective pinning of each flux line in the system.