How does a plant pathogenic fungus perceive its environment and cause disease? To answer this, research is directed towards understanding the genetic and biochemical networks that underlie the molecular interactions between fungi and plant host. This approach uses molecular genetics and biochemical analysis, coupled with high-throughput post-genomic technologies, to identify and characterize the gene expression networks, protein interactions, biochemical processes, signaling pathways and effector molecules that mediate the plant-fungal interaction. Focusing on economically important pathogens such as the devastating rice blast fungus M. oryzae and the mycotoxigenic fungi, such an approach would ultimately identify novel determinants of virulence that could be exploited as drug targets in the fight against these recalcitrant pathogens.

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2012

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Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection, Jessie Fernandez, Janet D. Wright, David E. Hartline, Christian Fernando Quispe, Nandakumar Madayiputhiya, and Richard A. Wilson

2011

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The Sugar Sensor, Trehalose-6-Phosphate Synthase (Tps1), Regulates Primary and Secondary Metabolism during Infection by the Rice Blast Fungus: Will Magnaporthe oryzae’s “Sweet Tooth” become Its “Achilles’ Heel”?, Jessie Fernandez and Richard A. Wilson

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Fungal Virulence and Development Is Regulated by Alternative Pre-mRNA 3′End Processing in Magnaporthe oryzae, Marina Franceschetti, Emilio Bueno, Richard A. Wilson, Sara L. Tucker, Concepción Gómez-Mena, Grant Calder, and Ane Sesma

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GATA-Family Transcription Factors in Magnaporthe oryzae, Cristian F. Quispe

2010

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An NADPH-Dependent Genetic Switch Regulates Plant Infection by the Rice Blast Fungus, Richard A. Wilson, Robert P. Gibson, Christian Fernandez Quispe, Jennifer A. Littlechild, and Nicholas J. Talbot

2009

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Oxygenase Coordination Is Required for Morphological Transition and the Host-Fungus Interaction of Aspergillus flavus, Sigal Horowitz Brown, James B. Scott, Jeyanthi Bhaheetharan, William C. Sharpee, Lane Milde, and Richard A. Wilson

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Under Pressure: Investigating the Biology of Plant Infection by Magnaporthe oryza, Nicholas J. Talbot and Richard A. Wilson

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Fungal Physiology: A Future Perspective, Richard A. Wilson and Nicholas J. Talbot

2005

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Fundamental Contribution of β-Oxidation to Polyketide Mycotoxin Production In Planta, Lori A. Maggio-Hall, Richard A. Wilson, and Nancy P. Keller

2004

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Deletion of the Δ12-Oleic Acid Desaturase Gene of a Nonaflatoxigenic Aspergillus parasiticus Field Isolate Affects Conidiation and Sclerotial Development, Perng Kuang Chang, Richard A. Wilson, Nancy P. Keller, and Thomas E. Cleveland

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Characterization of the Aspergillus parasiticus Δ12-Desaturase Gene: A Role for Lipid Metabolism in the Aspergillus-Seed Interaction, Richard A. Wilson, Ana M. Calvo, Perng-Kuang Chang, and Nancy P. Keller

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Two Δ9-Stearic Acid Desaturases Are Required for Aspergillus nidulans Growth and Development, Richard A. Wilson, Perng-Kuang Chang, Agnieszka Dobrzyn, James B. Ntambi, Robert Zarnowski, and Nancy P. Keller

2002

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Relationship between Secondary Metabolism and Fungal Development, Ana M. Calvo, Richard A. Wilson, Jin Woo Bok, and Nancy P. Keller

2001

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Cultivar-Dependent Expression of a Maize Lipoxygenase Responsive to Seed Infesting Fungi, Richard A. Wilson, Harold W. Gardner, and Nancy P. Keller

1998

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Mutational Analysis of AREA, a Transcriptional Activator Mediating Nitrogen Metabolite Repression in Aspergillus nidulans and a Member of the “Streetwise” GATA Family of Transcription Factors, Richard A. Wilson and Herbert N. Arst Jr.