Role of U.S. military research programs in the development of U.S.-licensed vaccines for naturally occurring infectious diseases

Authors

Lynn W. Kitchen, Military Infectious Diseases Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MDFollow

Document Type

Article

Date of this Version

2007

Citation

Vaccine 25 (2007) 7017–7030

Comments

U.S. Government Work

Abstract

U.S. military physicians and researchers have collaborated in the development of eight U.S.-licensed vaccines since 1934, when product efficacy requirements were added to product safety requirements mandated in 1902. These vaccines include influenza (1945), rubella (1969), adenovirus types 4 and 7 (1980), meningococcus A, C, Y,W-135 (1981), hepatitis B (1981), oral typhoid (1989), Japanese encephalitis (1992), and hepatitis A(1995). Current efforts include newadenovirus and Japanese encephalitis vaccines, and vaccines to prevent dengue, diarrhea due to enterotoxigenic E. coli, Campylobacter, and Shigella, malaria, hemorrhagic fever with renal syndrome, scrub typhus, meningococcus type B, and HIV infection. All vaccines currently administered to U.S. military forces must be licensed by the U.S. Food and Drug Administration (FDA).