U.S. Department of Defense
Date of this Version
1997
Citation
Published in The Lancet (December 1997) 350: 1855
Abstract
Clara Menendez and colleagues (Sept 20, p 844) show the protective effect of Deltaprim (3·125 mg pyrimethamine plus 25 mg dapsone) in infants exposed to intense transmission of Plasmodium falciparum. On the basis of post-treatment attack rates, they state, “The study shows that partly effective malaria control has modified the rate at which naturally acquired immunity develops”. We offer two alternative explanations.
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