False-negative direct immunofluorescence testing in vancomycin-induced linear IgA bullous dermatosis: a diagnostic pitfall

Authors

Aubrey E. Winn, Uniformed Services University of the Health Sciences
Erin L. Spillane, Womack Army Medical Center
Dave J. Peterson, Womack Army Medical Center
Leonard C. Sperling, Uniformed Services University of the Health Sciences
Jon H. Meyerle, Uniformed Services University of the Health Sciences

Date of this Version

2016

Citation

J Cutan Pathol 2016: 43: 802–804

Comments

U.S. Government Work

Abstract

Linear IgA bullous dermatosis (LAD) is an acquired immunobullous dermatosis that relies on direct immunofluorescence (DIF) testing showing linear deposition of immunoglobulin IgA along the basement membrane of the epidermis for diagnosis. We present a case that highlights the utility of repeating the DIF testing when initial immunofluorescence findings do not support the clinical findings of drug-induced LAD or contradict the histopathologic findings in routinely stained sections.