A BALB/c Congenic Strain of Mice That Carries a Genetic Locus (Ity^r) Controlling Resistance to Intracellular Parasites

Authors

Michael Potter, National Cancer Institute
Alison D. O'Brien, Uniformed Services University of the Health SciencesFollow
Emil Skamene, Montreal General Hospital Research Institute
Philippe Gros, Montreal General Hospital Research Institute
Adrien Forget, Université de Montréal
Patricia A. L. Kongshavn, Montreal General Hospital Research Institute
Judith S. Wax, National Cancer Institute

Date of this Version

1983

Citation

Infection and Immunity (1983), 40(3), p. 1234-1235

Abstract

BALB/c.DBA/2 Idh-1^b-Ity^r-Pep-3^b congenic mice were developed by introgressively backcrossing the Idh-1^b and Pep-3^b markers of DBA/2 mice onto the BALB/cπ mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ity^r gene. BALB/c.DBA/2 Idh-1^b-Ity^r-Pep-3^b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.