A BALB/c Congenic Strain of Mice That Carries a Genetic Locus (Ity^r) Controlling Resistance to Intracellular Parasites

Authors

• Michael Potter, National Cancer Institute
• Alison D. O'Brien, Uniformed Services University of the Health SciencesFollow
• Emil Skamene, Montreal General Hospital Research Institute
• Philippe Gros, Montreal General Hospital Research Institute
• Adrien Forget, Université de Montréal
• Patricia A. L. Kongshavn, Montreal General Hospital Research Institute
• Judith S. Wax, National Cancer Institute

Date of this Version

1983

Citation

Infection and Immunity (1983), 40(3), p. 1234-1235

Abstract

BALB/c.DBA/2 Idh-1^b-Ity^r-Pep-3^b congenic mice were developed by introgressively backcrossing the Idh-1^b and Pep-3^b markers of DBA/2 mice onto the BALB/cπ mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ity^r gene. BALB/c.DBA/2 Idh-1^b-Ity^r-Pep-3^b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.