Activation of a Translocated Human c-myc Gene by an Enhancer in the Immunoglobulin Heavy-Chain Locus

Authors

Adrian C. Hayday, King's College School of Medicine and DentistryFollow
Stephen D. Gillies, Massachusetts Institute of Technology
Haruo Saito, University of TokyoFollow
Charles Wood, University of Nebraska-LincolnFollow
Klas Wiman, Karolinska InstitutetFollow
William S. Hayward, Memorial Sloan-Kettering Cancer Center,
Susumu Tonegawa, Massachusetts Institute of TechnologyFollow

Document Type

Article

Date of this Version

1-26-1984

Comments

Published in Nature (January 26, 1984) 307: 334-340. Copyright 1984, Nature Publishing Group. Used by permission. http://www.nature.com/nature/journal/v307/n5949/abs/307334a0.html

Abstract

A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin’s lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q⁺ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.