Virology, Nebraska Center for


Date of this Version



Published in Nature (January 26, 1984) 307: 334-340. Copyright 1984, Nature Publishing Group. Used by permission.


A tissue-specific transcriptional enhancer element that is associated with the human immunoglobulin heavy-chain locus is defined. In a non-Hodgkin’s lymphoma that contains a translocated c-myc gene this enhancer is retained on the 14q+ chromosome and occurs within sequences shown to activate previously cryptic promoters of the c-myc gene.