Virology, Nebraska Center for


Date of this Version

January 1987


Published in JOURNAL OF VIROLOGY, Jan. 1987, p. 209-213, Vol. 61, No. 1 0022-538X/87/010209-05$02.00/0 Copyright © 1987, American Society for Microbiology. Used by permission.


Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(A)+ CD4 RNA, whereas uninfectible colon carcinoma and rhabdomyosarcoma cell lines synthesized no detectable T4 RNA. A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.

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