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Vomiting is a characteristic, although undesirable effect when using Compound 1080 (sodium monofluoroacetate) as a method of predator control for coyotes. Compound 1080 meat baits with (treatment) and without (control) an antiemetic, metoclopramide hydrochloride (MH), were fed to captive coyotes to determine whether MH would prevent vomiting. All treatment and control animals died as a result of consuming the 1080 bait with no difference between the groups in time from bait consumption to death. There was no significant difference between the number of treatment and control animals that vomited after consuming the baits. Likewise there was no difference between the treatment and control groups in the time from consuming 1080 to vomiting, the duration of the vomiting period, or the number of times each animal vomited. Despite indications in the literature to the contrary, MH did not prevent 1080-induced vomiting in coyotes.