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In view of resistance reported to have developed towards second generation anticoagulants and the problem of bait shyness and neophobia when acute rodenticides are used it becomes imperative that methods be evolved to overcome these problems. Attempts to potentiate anticoagulants for effective rodent control is a new concept with very few studies. Experiments using two non-steroid anti-inflammatory, drugs namely ibuprofen and phenylbutazone at 80 mg/kg and 50 mg/kg body weight respectively to potentiate the action of two second generation anticoagulants, brodifacoum and bromadiolone yielded positive results for Rattus rattus. The drugs reduced the lethal dose required for 100% mortality as well as days to death. Field trials confirmed laboratory findings.