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Bromadiolone, a new anticoagulant rodenticide, has been evaluated against laboratory rats and mice. Kill of both species was excellent, even when bromadiolone was offered for only one day in the presence of alternative food. Effectiveness against homozygous warfarin resistant rats was also demonstrated. Limited field trials on farms showed that after baiting for seven days with bromadiolone, warfarin resistant rat populations were substantially reduced although subsequent re-infestation occurred. Longer or continuous periods of baiting with bromadiolone would almost certainly prevent population increase, but government restrictions on the amount of bait approved for the trials did not allow this to be demonstrated.