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Thesis (M.S.)—University of Nebraska—Lincoln, 1938. Department of Chemistry.


Copyright 1938, the author. Used by permission.


Arsonated aromatic and aliphatic-aromatic ketones constitute a rather recent development in the chemistry of organic arsenicals.

This study was concerned with the preparation of acetophenone-arsonic acids and their derivatives containing a free hydroxyl group in the benzene nucleus. The most satisfactory types of arsenic compounds are the arseno and arsine oxide types.

Arsonated acetophenone derivatives can be prepared by a number of general methods. This experiment investigated the possibilities of the Hoesch reaction7 in the production of mixed ketones containing arsenic in the same benzene nucleus as free hydroxyl groups.

Several intermediate compounds were prepared and identified for the first time: 2-hydroxy-4-methoxy-5-nitroacetophenone, the corresponding amine and amine Hydrochloride.

Advisor: Cliff S. Hamilton.