Libraries at University of Nebraska-Lincoln
Document Type
Thesis
Date of this Version
1-14-1943
Citation
Thesis (M.S.)—University of Nebraska—Lincoln, 1943. Department of Chemistry.
Abstract
One of the characteristics of the molecule of therapeutically useful arsenicals is its amphoterism. In the search for ones of greater therapeutic value attention has been turned to compounds containing heterocyclic rings in the molecule. Interest in one type has been aroused because of the success of p-(4,6-diamino-1,3,5-triazin-2-ylamino) benzenearsonic acid in treating sleeping sickness. Since the pyrimidine ring is closely related to the 1,3,5-triazine, part of this problem was concerned with the synthesis of derivatives of p-aminobenzenearsonic acid with the amino group substituted by the pyrimidine ring and its derivatives.
Another type of interest was that in which the arsonic acid was directly linked to the pyrimidine ring. Pyridine arsonic acids have proved to be of therapeutic value, and the relationship of the pyrimidine to the pyridine ring made interesting the investigation of this type in the pyrimidine series.
Advisor: C.S. Hamilton
Comments
Copyright 1943, the author. Used by permission.