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Thesis (M.S.)—University of Nebraska—Lincoln, Department of Home Economics.


Copyright 1962, the author. Used by permission.


Although various investigators have suggested pantothenic acid requirements ranging from 5 mg (Elvehjem, ’51) to 10 to 15 mg daily (Krehl, ’53), the pantothenic acid requirement of human subjects has not been established. Previous work in this laboratory (Fox and Linkswiler, ’61) indicated that urinary pantothenic acid responds to changes in dietary intake. When young women were maintained on a diet providing approximately 3 mg of pantothenic acid for 15 days, urinary excretion exceeded intake. Moreover, when the intake was increased to either 8 or 13 mg, the excretion represented only from 40 to 50 per cent of the intake. It thus seemed worthwhile to study the response of subjects to a low dietary pantothenic acid intake over a longer period of time and to measure the response of subjects receiving higher levels of supplementation than in the previous study.

Advisor: Hazel M. Fox