Papers in the Biological Sciences


Date of this Version



Published in Developmental Cell 46 (August 6, 2018), pp 251–253.

doi 10.1016/j.devcel.2018.07.013

PubMed ID: 30086297


Copyright © 2018 Elsevier Inc. Used by permission.


Species with chromosomal sex determination are susceptible to an evolutionary tug-of-war over sex chromosome segregation. RNA silencing has been proposed to play a role in this intragenomic conflict. Reporting in Developmental Cell, Lin et al. (2018) demonstrate that RNA interference is key to this conflict as a genome defender. ... This work from Lin et al. (2018) provides exciting new evidence that RNA silencing may play a special role as a genome defense against native genes gone rogue. It will be interesting to see how these evolutionary games mediated by RNA silencing influence germline evolution and the dynamics of speciation.

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