Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence

Authors

Maria Pardos, Cincinnati Children’s Hospital Medical Center
Milena Korostenskaja, Cincinnati Children’s Hospital Medical Center & Florida Hospital for Children
Jing Xiang, Cincinnati Children’s Hospital Medical Center
Hisako Fujiwara, Cincinnati Children’s Hospital Medical Center
Ki H. Lee, Cincinnati Children’s Hospital Medical Center & Florida Hospital for Children
Paul S. Horn, Cincinnati Children’s Hospital Medical Center
Anna Byars, Cincinnati Children’s Hospital Medical Center
Jennifer Vannest, Cincinnati Children’s Hospital Medical Center
Yingying Wang, Cincinnati Children’s Hospital Medical Center & University of CincinnatiFollow
Nat Hemasilpin, Cincinnati Children’s Hospital Medical Center
Douglas F. Rose, Cincinnati Children’s Hospital Medical Center

Date of this Version

5-6-2015

Document Type

Article

Citation

2015 Maria Pardos et al.

Comments

Hindawi Publishing Corporation Behavioural Neurology Volume 2015, Article ID 237436, 10 pages http://dx.doi.org/10.1155/2015/237436

Abstract

Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ∼100ms, ∼150ms, ∼250ms, ∼350ms, and ∼450ms, respectively, elicited during the “match” condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy.