Chemical and Biomolecular Engineering, Department of
Date of this Version
3-17-2022
Document Type
Article
Citation
Porwal et al., STAR Protocols 4, 101685. https://doi.org/10.1016/ j.xpro.2022.101685
Abstract
We present a protocol to engineer a substrate-mediated delivery platform comprising hyaluronic acid-coated lipid nanoparticles (HALNPs) embedded into polyelectrolyte multilayer (PEM) films. This platform allows controlled spatiotemporal release of lipid nanoparticles (LNP) by embedding them within the polyelectrolyte multilayer films matrix. HALNP conjugate with antibodies also adds the ability for targeted delivery. The use of LNP enables this platform to encapsulate both hydrophobic and hydrophilic drugs. This platform can easily be reproduced and utilized for various biomedical drug delivery applications. For complete details on the use and execution of this protocol, please refer to Hayward et al. (2015, 2016a, 2016b), Hayward and Kidambi (2018), and Kidambi and Hayward (2022).
Included in
Biochemical and Biomolecular Engineering Commons, Biomedical Engineering and Bioengineering Commons
Comments
Open access.