Chemical and Biomolecular Engineering Research and Publications


Date of this Version

December 1996


The inventors of this patent are Drohan; William N. (Springfield, VA), Wilkins; Tracy D. (Blacksburg, VA), Velander; William H. (Lincoln,NE), Johnson; John L. (Blacksburg, VA)and the relavant information about this patent can be founnd from united states patent United States Patent No.5,589,604


Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic mammals that incorporate DNAs according to the present invention. Transgenic mammals of the present invention are produced by introducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature mammals and inherited in normal, mendelian fashion.