Chemical and Biomolecular Engineering Research and Publications


Date of this Version



The Inventors of this patent are Velander, William H. (Blacksburg, VA), Drohan, William N. (Springfield, VA), Lubon, Henryk (Rockville, MD), Johnson, John L. (Blacksburg, VA) The relevant information about this patent can be obtained from the website. United States Patent No. 6,984,772


A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.