Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818

Authors

Wei Zhang, University of Nebraska - LincolnFollow
Baobing Zhao, Shandong UniversityFollow
Liangcheng Du, University of Nebraska - LincolnFollow
Yuemao Shen, Xiamen UniversityFollow

Date of this Version

2017

Citation

Molecules 2017, 22, 1547; doi:10.3390/molecules22091547

Comments

Copyright © 2017, the authors. Licensee MDPI, Basel, Switzerland. Open access, Creative Commons Attribution license 4.0.

Abstract

Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5'-adenosine monophosphate-activated protein kinase).