α-VINYLLYSINE AND α-VINYLARGININE ARE TIME-DEPENDENT INHIBITORS OF THEIR COGNATE DECARBOXYLASES

Authors

David B. Berkowitz, University of Nebraska - LincolnFollow
Wan Jin Jahng, University of Nebraska - Lincoln
Michelle L. Pedersen, University of Nebraska - Lincoln

Document Type

Article

Date of this Version

9-17-1996

Citation

Bioorg Med Chem Lett. 1996 September 17; 6(18): 2151–2156. doi:10.1016/0960-894X(96)00366-6.

Comments

Copyright (c) 1996 Elsevier. Used by permission.

Abstract

(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from B. cadaveris, and L-arginine decarboxylase from E. coli, respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.