Metathesis-based synthesis of jasmonate and homojasmonate lactones, candidates for extracellular quorum sensing molecules in Candida albicans

Authors

Su C. Cho, University of Nebraska-Lincoln
Patrick Dussault, University of Nebraska-LincolnFollow
Amber D. Lisec, University of Nebraska-Lincoln
Ellen C. Jensen, University of Nebraska-LincolnFollow
Kenneth W. Nickerson, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

1998

Citation

J. Chem. Soc., Perkin Trans. 1, 1999, 193–196

Abstract

Ring-closing metathesis of jasmonate esters is shown to provide a rapid entry to jasmonate lactones. The lactones were investigated as possible quorum sensing molecules for the fungi Candida albicans. Assays demonstrated no effect on fungal morphology at concentrations up to 96 mM.