Date of this Version
Angewandte Chemie (International Edition, English; 2010) 49(24): 4,079–4,083. DOI: 10.1002/anie.201000695.
StereoElectronic Control of Unidirectional Reductive Elimination (SECURE) is provided by the cyclophane substituent on iodine(III). Computational and experimental studies demonstrate that out of plane steric bulk strongly destabilizes the reductive elimination transition state, and leads to regiochemical control. This approach should be general for high valent main group and transition metal ions.