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Ozonolysis is a powerful method for oxidative cleavage of alkenes using only oxygen and electricity. Moreover, by variation of substrate and conditions, ozonolysis can be used to generate a vareity of functional groups (Figure 1). However, experimenters must also consider the reactivity of ozone, the exothermicity of ozonolysis, and the potential for self-accelerating and dangerously exothermic decomposition reactions. The following is a brief introduction to the application of ozonolysis in academic labs, with an emphasis on safety.