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The following information is offered as a guide based upon our experience with application of ozone for organic oxidations and hydroperoxide synthesis. Please send suggestions, requests, or corrections to firstname.lastname@example.org.
Introduction and leading references
Overview of ozonolysis: Mechanism, Substrate reactivity, Typical reaction conditions, Reaction monitoring, Reaction work-ups
The following provides a brief introduction to the application of ozonolysis within academic labs. Ozonolysis remains among the most frequently used of methods for oxidative cleavage of alkenes. While best known as a means by which to introduce aldehydes and ketones, ozonolysis can also be used to generate other functional groups. An overview of some of the most common ozonolysis transformations illustrated in Figure 1; the reader is directed to a recent review for more information and leading references. A number of useful technical documents are available online.