Date of this Version
J. Ramanan, P. Z. Revesz, Mutations of adjacent amino acid pairs are not always independent, In: Mathematical Models and Computational Methods (joint proceedings of AMCSE-MMMAS-EAS), Imre J. Rudas, editor, INASE Press, pp. 75--79, October 2015.
Evolutionary studies usually assume that the genetic mutations are independent of each other. This paper tests the independence hypothesis for genetic mutations with regard to protein coding regions. According to the new experimental results the independence assumption generally holds, but there are certain exceptions. In particular, the coding regions that represent two adjacent amino acids seem to change in ways that sometimes deviate significantly from the expected theoretical probability under the independence assumption.
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