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Aspergillus nidulans Response to Environmental Cues Through the Regulation of Signaling Pathways

Samantha Reese, University of Nebraska - Lincoln


Filamentous fungi have the ability to explore the environment through polarized hypal growth. These surroundings are constantly changes, and filamentous fungi response to these altering environmental cues with the regulation of signaling pathways. The filamentous fungi Aspergillus nidulans has the genetic tool box to regulate polarized hyphal growth in non-preferred carbon sources, cell wall stress in the presence of antifungals, and specific enzyme secretion in the presence of different carbon sources. The regulation of these signaling pathways are vital to survival, however, there is little known about how these signaling pathways are regulated in A. nidulans. This thesis uses genetic engineering, bioinformatics, microscopy, and classical genetics to shed light on how these pathways are regulated to aid in the discovery of potential new antifungals and to increase bioindustral profits. The research conducted in this thesis suggest that; genes that regulate polarized growth also regulate secretion pathways, pathways that respond to cell wall stress can be an evolutionary adaptation, and the genetic manipulation of protein secretion pathway regulators can increase bioindustral yields.

Subject Area


Recommended Citation

Reese, Samantha, "Aspergillus nidulans Response to Environmental Cues Through the Regulation of Signaling Pathways" (2021). ETD collection for University of Nebraska-Lincoln. AAI28489816.