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Tame the Flame: Inflammation Is a Targetable Physiological Mechanism Underlying Poor Outcomes of Heat Stress in Finishing Sheep
This research focused on health management through the identification of suitable interventions in stressed livestock. For this investigation, we conducted two experiments. First, we determined whether administration of dexamethasone or fish oil to heat-stressed livestock to reduce systemic inflammation would mitigate metabolic deficits, enhance nutrient utilization, and improve health. We found that these interventions helped to reduce circulating inflammatory cytokines and improve respiration, muscle glucose metabolism, lipid homeostasis, cardiovascular function, and organ pathology in lambs exposed to 30 days of heat stress. In our second experiment, we performed transcriptomic analyses to identify the underlying mechanisms affecting young offspring following prenatal heat stress. Our primary objective was to determine gene expression changes in the left ventricular cardiac tissue of juvenile lambs affected by intrauterine stress. Through these analyses, we identified differences in gene expression affecting physiological pathways related primarily to elevated inflammatory signaling and disruption of growth regulation. The findings from these data will inform the development of strategies to mitigate the adverse consequences associated with inflammation-inducing events in livestock species.
Grijalva, Pablo Cesar, "Tame the Flame: Inflammation Is a Targetable Physiological Mechanism Underlying Poor Outcomes of Heat Stress in Finishing Sheep" (2023). ETD collection for University of Nebraska-Lincoln. AAI30813414.