Date of this Version
Journal of Molecular Structure 1287 (2023) 135700. https://doi.org/10.1016/j.molstruc.2023.135700
The quinoline molecule is a chemical motif showing a highly promising pharmacological potential. Its numerous derivatives introduced into medicine revolutionized in the treatment of many entities of disease. The presence of the quinoline system in the structure of phenothiazines made it possible to obtain new aza- and diazaphenothiazine derivatives that show promising anticancer potential. The aza-analogs of the phenothiazines are structurally modified phenothiazines by the substitution of one or both benzene rings in the phenothiazine ring system with various azine rings. This approach to the strategy of obtaining new substances with biological potential can be classified as molecular hybridization methods consisting of the combination of two or more pharmacophores to develop compounds with improved properties. Recently, valuable reviews on phenothiazines have appeared in the scientific literature, but they focus on dibenzothiazines. This review summarises the knowledge on the anticancer activity of isomeric quinobenzothiazines, diqinothiazines, and quinobenzothiazinum salts, which are modified phenothiazines with one and two quinoline rings, respectively, against different types of cancer cell lines. Hybridization of these two leading structures, phenothiazines and quinoline, both very important in medicinal chemistry, resulted in obtaining a very large group of compounds with diverse structures and a diverse anticancer activity.