Date of this Version
Vestergaard, M., Bingham G.V., Gouin S. G., Pederson M. S., Pates H. V., Zellwegger M. (2010). MOSQUITO NET WITH DINOTEFURAN AND PBO FOR KILLING MOSQUITOES, ESPECIALLY MOSQUITOES WITH PYRETHROID RESISTANCE. PCT: WO 2010/118743 Al.
Dinotefuran and PBO is used for killing mosquitoes, as PBO increases the knockdown speed of Dinotefuran.
The present invention relates to insecticidal mosquito nets containing PBO in combination with an insecticide.
One of the methods to counteract malaria is the use of commercially available long lasting insecticidal mosquito nets for protecting humans from the bite of Anopheline mosquitoes that carry malaria. Whereas the typically applied pyrethroids have been used successfully as insecticides on such nets due to their rapid knockdown effect, there is currently a critical increased resistance to pyrethroids observed among those mosquitoes. One type of resistance is metabolic, which is counteracted by applying piperonyl butoxide (PBO) simultaneously with a pyrethroid to the mosquito when resting on the net. The PBO works as an inhibitor of the resistance associated metabolic enzymes and increases the mortality rate of the pyrethroid resistant mosquitoes. Another type of resistance is through a mutation at the target site of the pyrethroid, known as knockdown-resistance (kdr), which significantly slows the knockdown effect when the mosquito rests on the net and gives the mosquito the possibility to bite before paralysis (followed by death).