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The use of sterile males to control a cage population of a laboratory strain of Anopheles quadrimaculatus was not successful, even though 80 to 90% of the females laid sterile egg clutches. At the ratio of sterile males to normal males being used, complete sterility should have been quickly achieved. Subsequent studies of the survival and sexual vigor of these sterile males indicated that only a small number, about 5%, of the released males were actually competing with normal males for the uninseminated females. Thus, until a more hardy and sexually vigorous male A. quadrimaculatus can be reared in the laboratory, the use of the sterile-male technique to control this insect seems impractical.