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The in-crop use of pesticides is allowed only after establishment of a crop tolerance with supporting residue data for the crop. Residue data from different regions and pesticide application methods (hand treatment, aerial broadcast, etc.) are required. Most rodenticide uses have been considered as non-crop since they are generally applied in and around rodent burrows and runways. Because of this, rodenticides do not generally have tolerances or residue information for crop use. Recent inquiries by the Environmental Protection Agency (EPA), a review of current rodenticide labels, and new pesticide laws, suggest the need for reevaluating the question of in-crop use of rodenticides. This paper reviews the current situation regarding tolerances, crop residue research and some possible approaches to solve this important problem. This information has national significance since EPA is the responsible agency for setting food crop tolerances in the United States.