Honors Program


Date of this Version

Fall 10-28-2019

Document Type



Sabloak K. 2019. Role of Parathyroid Hormone-Related Protein in Pancreatic Cancer Associated Cachexia. Undergraduate Honors Thesis. University of Nebraska-Lincoln.


Copyright Krishti Sabloak 2019


Pancreatic cancer (PC) is one of the deadliest forms of cancer as early detection is minimal and is only diagnosed once the cancer has already metastasized beyond the pancreas. The treatments available for pancreatic cancer are rigorous and can cause many side effects. More than 80% of the PC patients develop a muscular wasting syndrome called Cachexia. Cancer Associated Cachexia (CAC) is characterized by the wasting of muscle and adipose tissue. Cachexia impairs the patients’ quality of life and endurance for possible treatments. Browning is a process which white adipose tissue is converted to brown adipose tissue and is considered to be a key facilitator in regulating weight loss. Here, we will explore the association between pro-cachectic factors and the development of cachexia in patients with pancreatic cancer.