Date of this Version
Algahimi, N. 2022. Expression of Glycolysis, Oxidative Phosphorylation, and the Hippo Signaling Pathway in Preeclampsia. Undergraduate Honors Thesis. University of Nebraska-Lincoln.
Preeclampsia (PE) is a disease of human pregnancy characterized by hypertension and proteinuria. PE affects 3-10% of all pregnancies and can often have severe consequences, such as premature labor induction. The mechanisms by which preeclampsia develops and progresses remain largely unknown which makes treatment especially difficult. This study seeks to elucidate potential mechanisms of pathogenesis using relative gene expression values between healthy and preeclamptic placenta cells. Gene expression values, collected using RNA sequencing, were analyzed for glycolysis, oxidative phosphorylation, and mechanotransduction. Significance testing demonstrated change in expression for the first step of glycolysis, complex I and complex IV in oxidative phosphorylation, and within the secondary part of the Hippo Kinase Signaling cascade. This study presents evidence of the role both metabolic and mechanical signaling pathways play in the progression of PE.