U.S. Department of Agriculture: Animal and Plant Health Inspection Service

 

Authors

Patricia Ceger, Integrated Laboratory SystemsFollow
Natalia Garcia-Reyero Vinas, The United States Army Corps of Engineers
David Allen, Integrated Laboratory Systems
Elyssa Arnold, United States Environmental Protection Agency
Raanan Bloom, Food and Drug Administration
Jennifer C. Brennan, United States Environmental Protection Agency
Carol Clarke, United States Department of AgricultureFollow
Karen Eisenreich, United States Environmental Protection Agency
Kellie Fay, United States Environmental Protection Agency
Jonathan Hamm, Integrated Laboratory Systems
Paula F.P. Henry, United States Geological Survey
Katherine E. Horak, USDA APHIS NWRCFollow
Wesley Hunter, Food and Drug Administration
Donna Judkins, United States Environmental Protection Agency
Patrice Klein, United States Department of Agriculture
Nicole Kleinstreuer, National Institute of Environmental Health Sciences (NIEHS)
Kara Koehrn, United States Environmental Protection Agency
Carlie A. LaLone, United States Environmental Protection Agency
James P. Laurenson, Food and Drug Administration
Jessica K. Leet, Columbia Environmental Research Center
Anna Lowit, United States Environmental Protection Agency
Scott G. Lynn, United States Environmental Protection Agency
Teresa Norberg-King, United States Environmental Protection Agency
Edward J. Perkins, The United States Army Corps of Engineers
Elijah J. Petersen, National Institute of Standards and Technology
Barnett A. Rattner, United States Geological Survey
Catherine S. Sprankle, Integrated Laboratory Systems
Thomas Steeger, United States Environmental Protection Agency
Jim E. Warren, United States Department of Agriculture
Sarah Winfield, Food and Drug Administration
Edward Odenkirchen, United States Environmental Protection AgencyFollow

Date of this Version

8-1-2022

Citation

Regulatory Toxicology and Pharmacology 133 (2022) 105195

doi:10.1016/j.yrtph.2022.105195

Comments

U.S. government work

Abstract

U.S. regulatory and research agencies use ecotoxicity test data to assess the hazards associated with substances that may be released into the environment, including but not limited to industrial chemicals, pharmaceuticals, pesticides, food additives, and color additives. These data are used to conduct hazard assessments and evaluate potential risks to aquatic life (e.g., invertebrates, fish), birds, wildlife species, or the environment. To identify opportunities for regulatory uses of non-animal replacements for ecotoxicity tests, the needs and uses for data from tests utilizing animals must first be clarified. Accordingly, the objective of this review was to identify the ecotoxicity test data relied upon by U.S. federal agencies. The standards, test guidelines, guidance documents, and/or endpoints that are used to address each of the agencies’ regulatory and research needs regarding ecotoxicity testing are described in the context of their application to decision-making. Testing and information use, needs, and/or requirements relevant to the regulatory or programmatic mandates of the agencies taking part in the Interagency Coordinating Committee on the Validation of Alternative Methods Ecotoxicology Workgroup are captured. This information will be useful for coordinating efforts to develop and implement alternative test methods to reduce, refine, or replace animal use in chemical safety evaluations.

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