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Scientometrics is an important field of information science as it represents a unique set of techniques and tools for the monitoring and analysis of information resources and for the management of knowledge in social and organizational contexts. This article analysed the various Scientometric components of the articles published by top six universities of Tamil Nadu from 2000-2017. The study identifies research trend, characteristics growth and collaboration pattern of published literature. The analysis of data reveals that the average growth rate increases at the rate of 9.76%. Further, the average citation per paper observed is 12.18%. High degree of international collaboration is notified and USA and South Korea are found to be the most preferred collaborative countries. The CAGR calculated for six universities are 9.76. The major research publications outputs are from the field of Chemistry, Crystallography and Pharmacy.