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Globally, digital publishing innovations have been shown to be effective in breaking down book production and distribution barriers. However, there has been a dearth of studies on digital publishing innovations (D.P.I.) in Nigeria, particularly as it relates to predictors of innovation adoption. This study, therefore, examined the extent to which perceived contextual factors and perceived relative advantage correlate with the extent of adoption of digital publishing innovations with a view to validating a framework to aid the adoption of digital publishing in developing environments. A framework modifying the diffusion of innovations theory and the Technology, Organisation, Environment theory was designed. A total of 109 copies of a questionnaire were administered on purposively selected publishers to test the framework, and data were analysed using correlation and multiple regression at the 0.05 level of significance. Findings indicate that perceived relative advantage (r = 0.54), market readiness (r = 0.54), business uncertainty (r = 0.54) and enabling facility (r = 0.28) had significant correlations with D.P.I. adoption. The four correlates had a strong joint prediction on adoption of D.P.I. (F = 4.30, R2 =.27), accounting for 26.8% of its variance. Individually, the four variables were valid to predict the adoption level of different aspects of digital publishing, indicating that the framework is valid in predicting the adoption of digital publishing.