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This paper investigated the possibility of utilizing SCImago Journal Rank (SJR), Eigenfactor Score and Google H5 index indicator as an alternative to the Journal Impact Factor (JIF) for quality assessment in the field of biochemistry and molecular biology. Principal factors such as researchers and librarians concerns of methods of scientific journal ranking, publication of language, analysis time and self-citation impact are looked into across indicated options and alternatives. The SJR, ES, Google H5 and JIF scores and ranking order of biochemistry and molecular biology journals were downloaded from their relevant websites. Pearson’s and Spearman’s correlation coefficients were gauged to weigh relationship between these journal quality metrics. Nominated coefficients were embraced for evaluating direct and monotonic relationships of chosen variables and ranking measures. A constructive correlation was detected among the scores and ranking order based on SJR, ES, Google H5 and JIF of selected biochemistry and molecular biology journals. Consequently, scholars, academics and researchers in biochemistry and molecular biology can use the SJR, ES and Google H5 indicators as replacements to JIF for appraisal of scientific journals in the field.