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The main purpose of this study is to determine the perception of open access system among the library professionals, and the factors they consider while selecting open access journals for publication. The both printed and online questionnaire was designed for data collection. A total of 116 LIS (Library and Information Science) professional’s responses were collected through both online and offline questionnaire from different academic libraries in Odisha. The study shows that majority of the LIS professionals of different academic institutions of Odisha are aware about open access routes. The results of the study revealed that majority of respondents are aware about open access routes and they have considered open access publication as Scholarly Literature. But majority of authors do not support to pay Article Processing Charges (APC) for getting their research papers published through Open Access journals.