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The health related lifestyle behavior has been neglected in Nigerian Universities and as such causing deaths among the lecturers. Living a healthy lifestyle could reduce heart diseases, blood pressure and diabetes. The study adopted survey method. The population of the study was 5,310 lecturers across the six Federal Universities in South West, Nigeria. From the population, 372 were sampled. Structured questionnaire were used to collect data. From the 372 copies of questionnaire distributed; 278 were returned which gave 75% response rate. Data were analyzed using percentages, mean, standard deviation as well as relationship. Findings revealed that all information gathered on healthy workplace environment has positive significant relationship with job performance (teaching effectiveness) of lecturers (r=0.43, P<0.05). Healthy lifestyle practices has no significant relationship with job performance (r=0.38, P>0.05). Healthy workplace culture also has significant relationship with job performance of lecturers (r=0.33, P<0.05). Moreover, healthy workplace environment and Healthy workplace culture are the most important factors that contribute to job performance (teaching effectiveness) of lecturers. The study therefore, recommended that there is need for university management to provide health information and also look into the issues of healthy environment and healthy culture in a workplace for improved job performance.