The purpose of this study was to assess Research Data Management (RDM) capabilities at the University of Ghana (UG). The study focused on four key capability elements: policy framework, technological infrastructure, skills and knowledge, and support services. It explored the extent to which RDM is embedded in research practices at UG and provides insight into the preparedness of UG to develop RDM. A qualitative case study method was adopted for the study and data was gathered using semi-structured interviews and document analysis. The instrument for the assessment was informed by the Collaborative Assessment for Research Data Infrastructure and Objectives (CARDIO) Matrix tool and respondents were drawn from the Library, IT department, Research Office and senior researchers. The results of the study show that RDM at UG is currently underdeveloped but with immense potential for growth. Though there is no formal RDM infrastructure in place, RDM is considered an essential research integrity issue. Capabilities were generally found to be limited, uncoordinated and not officially instituted. The study recommends that a clear and comprehensive policy framework for RDM should be developed to articulate RDM aspirations and express management’s commitment. It also recommends that research support staff should be supported to build their capacity for RDM promotion and support.