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The study is aimed to investigate the scientific research productivity of India’s NIRF first ranked higher academic & research institute, Indian Institute of Science (IISc), Bangalore for a period of 05 years during 2014-2018. A total of 12,130 research papers were retrieved as SCIE publication from WoS bibliographical database and analyzed. The study is focused to find out the year wise institutional contribution in research, compound annual growth rate, areas of interest, collaborating institutions and countries, mode of publications, research funding agencies, prolific journals, prolific authors, authorship pattern, degree of collaborations etc. Different scientometric tools and techniques were used to analyze the data and interpretation has been done accordingly to draw out the meaningful result in evaluating the research productivity of the institute.